Process for the production of 17.alpha.-ethinyl-17.beta.-hydroxy

Details Process for the production of 17.alpha.-ethinyl-17.beta.-hydroxy Process for the production of 17.alpha.-ethinyl-17.beta.-hydroxy

1988-03-31

1990-05-08

Robinson, Douglas W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Cyclopentanohydrophenanthrene ring system containing

514178, 514182, 552505, 552644, 552648, C07J 100, A61K 3156

Patent

active

049236407

ABSTRACT:
A process for the production of 17.alpha.-ethinyl-17.beta.-hydroxy-18-methyl-4,15-estradien-3-one is described comprising reacting a 17-enolester of formula II ##STR1## wherein R.sub.1 represents an alkyl radical with 1-3 carbon atoms and

REFERENCES:
patent: 4016269 (1977-04-01), Hofmeister et al.
patent: 4036695 (1977-07-01), Petzoldt et al.
patent: 4081537 (1978-03-01), Hofmeister et al.
Chemical Abstracts 75(1): 6182f 7/5/71.
Chemical Abstracts 8th Collective Index 1967-1971, "Gona-1,3,5(10),15-Tetraen-17-One-13-Ethyl--3 Methoxy".
Ichiro Minami et al., "New Synthetic Methods for .alpha., .beta.-Unsaturated Ketones, Aldehydes, Esters and Lactones by the Palladium-Catalyzed Reactions of Silyl Enol Ethers, Ketene Silyl Acetals, and Enol Acetates with Allyl Carbonates," Tetrahedron, vol. 42, No. 11, p. 2971, (1986).

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