Process for the production of 1-(aminomethyl) cyclohexane acetic

Details Process for the production of 1-(aminomethyl) cyclohexane acetic Process for the production of 1-(aminomethyl) cyclohexane acetic

1991-11-01

1992-08-04

Shippen, Michael L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

C07C 6108

Patent

active

051360918

ABSTRACT:
A new process is described for the production of 1-(aminomethyl)cyclohexane acetic acid, a pharmaceutical agent used as an anticonvulsant. For this purpose a (1-cyanocyclohexyl)-malonic acid dialkyl ester is decarbalkoxylated to the corresponding (1-cyanocyclohexyl)acetic acid alkyl ester, then transesterified with a benzyl alcohol and finally hydrogenated to form the end product.

REFERENCES:
patent: 4024175 (1977-05-01), Satzinger et al.
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patent: 4956473 (1990-09-01), Mettler et al.
patent: 4958044 (1989-11-01), Mettler et al.
Krapcho et al., Synthesis (1982), pp. 805 to 821, pp. 893 to 914.
New et al., Synthesis, (1983), pp. 388 to 389.
Drugs of the Future, vol. 9, No. 6, (1984), pp. 418 and 419.
Aneya et al., Tetrahedron Letters, vol. 24, No. 23, (1983), pp. 4641 to 4644.

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