Process for the production of 1-(aminomethyl) cyclohexane acetic

Details Process for the production of 1-(aminomethyl) cyclohexane acetic Process for the production of 1-(aminomethyl) cyclohexane acetic

1991-07-10

1992-07-14

Brust, Joseph Paul

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitriles

558431, C07C25546

Patent

active

051304554

ABSTRACT:
A new process is described for the production of 1-(aminomethyl)cyclohexane acetic acid, a pharmaceutical agent used as an anticonvulsant. For this purpose a (1-cyanocyclohexyl)-malonic acid dialkyl ester is decarbalkoxylated to the corresponding (1-cyanocyclohexyl)acetic acid alkyl ester, then transesterified with a benzyl alcohol and finally hydrogenated to form the end product.

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New et al., Synthesis (1983), pp. 388 to 389.
Drugs of the Future, vol. 9, No. 6, (1984), pp. 418 and 419.
Aneya et al., Tetrahedron Letters, vol. 24, No. 23, (1983), pp. 4641 and 4644.

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