Process for the production of [1,1-dithienyl-(3)-1-hydroxypropyl

Details Process for the production of [1,1-dithienyl-(3)-1-hydroxypropyl Process for the production of [1,1-dithienyl-(3)-1-hydroxypropyl

1978-01-05

1979-11-20

Schwartz, Gerald A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D33316

Patent

active

041750888

ABSTRACT:
[1,1-dithien-(3)-yl-1-hydroxy-(3)-propyl]-[1-phenyl-1-hydroxy-(2)-propyl]-a mine is prepared by condensing thien-(3)-yl lithium with a .beta.-halogen propionic acid alkyl ester of the formula ##STR1## where R is a lower alkyl group and Hal is chlorine, bromine or iodine, in an inert medium at a temperature below -50.degree. C. to form a compound of the formula ##STR2## which is then reacted with 2-amino-1-hydroxy-1-phenylpropane in an inert medium in the presence of a basic compound. The product cn be converted to [1,1-dithien-(3)-yl-(1)-propen-(3)-yl]-[1-phenyl-(2)-propyl]-amine by dehydration.

REFERENCES:
patent: 3251858 (1966-05-01), Thiele et al.
patent: 3766173 (1973-10-01), Thiele et al.
Morrison & Boyd, "Organic Chemistry", pp. 91-92, 456-457, 676, 683, 742, 840-841.

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