Process for the prepartion of cefatrizine 1,2-propylene glycolat

Details Process for the prepartion of cefatrizine 1,2-propylene glycolat Process for the prepartion of cefatrizine 1,2-propylene glycolat

1989-02-23

1990-10-23

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D50104

Patent

active

049653555

ABSTRACT:
Cefatrizine 1,2-propylene glycolate is prepared by reacting p-hydroxyphenylglycine chloride hydrochloride with 7-amino-3-iodomethyl-3-cephem-4-carboxylic acid, and then reacting the thus obtained novel intermediate, 7-[D(-)-.alpha.-amino-.alpha.-(p-hydroxyphenyl)-acetamido]-3-iodomethyl-3- cephem-4-carboxylic acid, with the sodium salt of 1,2,3-triazol-4(5)-thiol in 1,2-propylene glycol. The addition of water to the reaction mixture causes the cefatrizine, 1,2-propylene glycolate to precipate.

REFERENCES:
patent: 3970651 (1976-07-01), Kaplan et al.

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