Process for the preparation substituted anilino acids

Details Process for the preparation substituted anilino acids Process for the preparation substituted anilino acids

1982-07-21

1984-01-03

Reamer, James H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

562433, C07C 9900

Patent

active

044243960

ABSTRACT:
Anilino acids of the formula ##STR1## wherein R is H or a metal cation; R.sub.2 is hydrogen or lower alkyl of 1 to 5 carbon atoms, lower alkenyl of 2 to 5 carbon atoms, lower haloalkyl of 1-4 carbon atoms, lower haloalkenyl of 2 to 4 carbon atoms, or lower cycloalkyl of 3 to 4 carbon atoms, Y is hydrogen, chloro, methyl group, or trifluoromethyl group, and X is hydrogen, chloro, or fluoro are prepared by reaction of an aryl halide of the formula ##STR2## where X.sup.1 is chloro or fluoro and X and Y are as defined above with the proviso that when X.sup.1 is chloro, X is hydrogen or chloro, and when X and Y are both chloro, X.sup.1 is fluoro with an .alpha.-amino acid of the formula ##STR3## where R and R.sub.2 are as defined above.

REFERENCES:
patent: 3484487 (1969-12-01), Dix
patent: 4096185 (1978-06-01), Seiwell
patent: 4226802 (1980-10-01), Anderson et al.
patent: 4243819 (1981-01-01), Henrick et al.
Zahn et al., Biochem Z, vol. 325, pp. 333-338, (1954).

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