Process for the preparation of zomepirac and related compounds

Details Process for the preparation of zomepirac and related compounds Process for the preparation of zomepirac and related compounds

1981-06-04

1983-02-22

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D207337, C07D20731

Patent

active

043749976

ABSTRACT:
Zomepirac and its analogs have been prepared from a 5-aroyl-3-hydroxycarbonyl-4-substituted pyrrole-2-acetic acid via acidic decarboxylation.

REFERENCES:
patent: 3752826 (1973-08-01), Carson
patent: 3952012 (1976-04-01), Carson
patent: 4048191 (1977-09-01), Carson
patent: 4070368 (1978-01-01), Carson
Finai; Org. Chem., 2, 5th ed., p. 670, (1975).
Carson et al.; J. Med. Chem., vol. 16, No. 2, p. 173, (1973).
Patai, S. (editor); Chem. Carboxylic Acids and Esters, Chap. 12, p. 589, (1969).

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