Process for the preparation of vincristine

Details Process for the preparation of vincristine Process for the preparation of vincristine

1986-06-02

1988-08-30

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

C07D51904

Patent

active

047678550

ABSTRACT:
The present invention relates to a process for the preparation of vincristine.
The process for the semisynthesis of vincristine according to the present invention comprises oxidizing vinblastine or its salts with chromic acid or its salts, in ethyl acetate at a low temperature.

REFERENCES:
patent: 3899493 (1975-08-01), Jovanovics et al.
patent: 4375432 (1983-03-01), Conrad
patent: 4659816 (1987-04-01), Szantay et al.

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