Process for the preparation of vincadifformine and derivatives

Details Process for the preparation of vincadifformine and derivatives Process for the preparation of vincadifformine and derivatives

1974-06-18

1976-10-19

Rizzo, Nicholas S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260283SY, 26029354, 260326N, 326 A, C07D47116, C07D51904

Patent

active

039870480

ABSTRACT:
In the preparation of vincadifformine and derivatives thereof, such as 3-oxo-1,2-dehydroaspidospermidine and 1,2-dehydro-aspidospermidine, 2-hydroxy-tryptamine or a derivative thereof substituted in the benzene ring is condensed with dimethyl 4-ethyl-4-formyl-pimelate to form an oxindolic lactam-ester as the first step of the process. By means of this process, vincadifformine and its derivatives can be obtained in a smaller number of steps than in known processes.

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