Process for the preparation of urokinase derivatives

Details Process for the preparation of urokinase derivatives Process for the preparation of urokinase derivatives

1988-10-11

1990-01-09

Rosenberg, Peter D.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

435212, 435215, C12N 900

Patent

active

048928267

ABSTRACT:
A process for making urokinase derivatives having a sulfhydryl group incorporated into a remnant of urinary plasminogen activator. The process comprises reducing disulfide bridges in the presence of arginine and incorporating a desired compound having a sulfhydryl containing group into the structure through the formation of a disulfide bridge.

REFERENCES:
patent: 4326033 (1982-04-01), Holleman
patent: 4349630 (1982-09-01), Maximenko
patent: 4525465 (1985-06-01), Someno
patent: 4536391 (1985-08-01), Miyozaki
patent: 4545988 (1985-10-01), Nakayama
Robbins et al., Biochemistry, 25, 3603-3611 (1986), "Covalent Molecular Weight 92,000 Hybrid Plasminogen Activator Derived from Human Plasmin Amino-Terminal and Urokinase Carboxyl-Terminal Domains".
Sumi et al., Journal of Biological Chemistry, 258, 8014-8019 (1983), "A Functionally Active Heavy Chain Derived from Human High Molecular Weight Urokinase".
Winkler and Blaber, Biochemistry, 25, 4041-4045 (1986), "Purification and Characterization of Recombinant Single-Chain Urokinase Produced in Escherichia coli".
Maksimenko et al., Thrombosis Research, 38, 277-288 (1985), "Water-Soluble Urokinase Derivatives of Combined Action".
Maksimenko et al., Thrombosis Research, 38, 289-195 (1985), "Water-Soluble Urokinase Derivatives with Increased Affinity to the Fibrin Clot".

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