Process for the preparation of unsymmetrically 1,3-disubstituted

Details Process for the preparation of unsymmetrically 1,3-disubstituted Process for the preparation of unsymmetrically 1,3-disubstituted

1977-05-25

1979-04-17

Randolph, John D.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

260349, 260456A, 260553R, 560 24, A61K 3117

Patent

active

041501462

ABSTRACT:
The invention relates to the preparation of unsymmetrically 1,3-disubstituted nitroso ureas from the corresponding N-substituted alkyl-N-nitrosocarbamoyl azide which is reacted with an amine, a diamine, an aminoalcohol, an aminoacid or an aminoacid derivative. The N-nitrosocarbamoyl azide is obtained by reacting the corresponding alkylcarbamoyl azide with nitrogen tetroxide in the cold. The alkylcarbamoyl azide is obtained by reacting the corresponding isocyanate with an alkali metal azide.
The invention further relates to novel nitroso ureas obtained thereby, to novel N-substituted alkyl-N-nitrosocarbamoyl azides, and to novel therapeutic compositions containing, as the active ingredient, the novel nitroso ureas.

REFERENCES:
eisenbrand et al., Z. Krebsforch, Klin. Onkol., 1976, 86 (3), pp. 279-286 (Eng.), Chemical Abstracts vol. 85, Abst. 85: 159,373a (1976).
Johnston et al., J. Med. Chem. vol. 9, pp. 892-911 (1966).
Garrett et al., J. Pharm. Sci., vol. 55, pp. 702-710 (1966).
Garrett et al., Chem. Abst. vol. 65, col. 7035 (1966).

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