Process for the preparation of thiophene derivatives and thiophe

Details Process for the preparation of thiophene derivatives and thiophe Process for the preparation of thiophene derivatives and thiophe

1978-05-30

1980-08-26

Trousof, Natalie

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549 78, C07D33324, C07D33328

Patent

active

042196590

ABSTRACT:
An .alpha.-(2-thienyl)propionic acid can easily be prepared in a high yield and high selectivity by reacting a 2-(dihaloacetyl)thiophene which is easily obtainable by acetylation and halogenation of a substituted or unsubstutitued thiophene, with a methylmetal compound and then reacting an alkali metal hydroxide with the reaction product. .alpha.-(2-Thienyl)propionic acids are useful compounds from which, for example, thioprofenic acid can easily be prepared. Thioprofenic acid is known as an anti-inflammatory agent. As reaction intermediates, 1-(2-thienyl)-1-dihalomethylethanols can be obtained. Which are novel and useful compounds.

REFERENCES:
patent: 2226645 (1940-12-01), Thomas et al.
patent: 2921940 (1960-01-01), Ransden
patent: 3097206 (1963-04-01), Zirkle
Blumbergs, P. et al., J. Org. Chem., vol. 37 (1972), pp. 1248-1251.
Hartough, Howard D., "Thiophenye and Its Derivatives." Interscience Publ. (1952), pp. 344-349 at p. 349.
Roberts, John D. et al., "Basic Principles of Organic Chemistry." W. A. Benjamin, Publ. (1973), pp. 492-493.

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