Process for the preparation of thiophene derivatives and also ne

Details Process for the preparation of thiophene derivatives and also ne Process for the preparation of thiophene derivatives and also ne

1990-12-20

1992-11-24

Siegel, Alan

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

544379, 546212, 546213, 548527, 549 61, 549 68, 549 69, C07D41300, C07D40500, C07D33338, C07D33336

Patent

active

051663465

ABSTRACT:
Process for the preparation of thiophene derivatives and also new dihydrothiophene 1-oxides.
Thiophene derivatives having an--optionally substituted--amino group on the thiophene ring are prepared by dehydrogenating dihydrothiophenes, substituted in a manner identical to that of the desired thiophene derivatives, by means of H.sub.2 O.sub.2, the dihydrothiophenes being reacted with H.sub.2 O.sub.2 in a first reaction stage in a neutral medium to give the corresponding sulfoxides, which are then rearranged into the thiophene derivatives by means of acid in the second reaction stage.
The dihydrothiophene 1-oxides formed as intermediates in this reaction are new compounds. Like the thiophene derivatives formed from them by rearrangement with acid, they are intermediates, mainly in the sector of plant protection agents and pharmaceuticals.

REFERENCES:
patent: 2443598 (1948-06-01), Cheney et al.
patent: 3445473 (1969-05-01), Ruschig et al.
patent: 3855243 (1974-12-01), Ruschig
patent: 4239897 (1980-12-01), Rossy et al.
patent: 4242518 (1980-12-01), Rossy et al.
Fieser et al., Reagents for Organic Synthesis, vol. 4, p. 8.
W. Theilheimer, Synthetic Methods of Organic Chemistry, vol. 17, p. 233, 1963.
A. P. Stoll & R. Suess, Helvetica Chimica Acta, vol. 57, Fasc. 8 (1974) Nos. 269-270, pp. 2487-2492.
T. Takaya et al., Bull. Chem. Soc. Japan, vol. 41 (1968), pp. 2086-2095.

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