Process for the preparation of the (R) stereoisomer of the monob

Details Process for the preparation of the (R) stereoisomer of the monob Process for the preparation of the (R) stereoisomer of the monob

1991-04-26

1993-07-20

Tsang, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

514903, 549218, A61K 31665

Patent

active

052293777

ABSTRACT:
A process for preparing the (R) stereoisomer of 2,2-bis(hydroxmethyl)-tetrahydrofuran monobutyrate comprising subjecting the dibutyric ester of the 2,2-bis(hydroxymethyl)-tetrahydrofuran to enzymatic hydrolysis. The invention also relates to the novel (R) stereoisomer prepared by the instant process and to its more stable forms. In addition, the invention relates to the use of the (R) stereoisomer in preparing stereoisomers of pharmacologically active compounds and to certain specific stereoisomers produced thereby.

REFERENCES:
patent: 4673672 (1987-06-01), Houlihan et al.
patent: 5010067 (1991-04-01), Handley et al.
patent: 5064816 (1991-11-01), Houlihan et al.
Houlihan et al., Lipids 22(11), 884-90 (1987).
Houlihan et al., J. Lipid Mediators 2(5), 295-307 (1990).

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