Process for the preparation of the enantiomers of 2-(2-fluoro-4-

Details Process for the preparation of the enantiomers of 2-(2-fluoro-4- Process for the preparation of the enantiomers of 2-(2-fluoro-4-

1995-12-22

1998-11-24

Richter, Johann

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

562402, 549371, C07B 5700, C07B 5500

Patent

active

058409645

ABSTRACT:
A process for the preparation of 2-(2-fluoro-4-biphenyl)propianic acid enantiomers comprising a II order resolution of ketals of formula ##STR1## wherein R.sub.1 ad R.sub.2 have the meanings reported in the description; the asterisk shows the chiral carbon atom and the asymmetric carbon atoms marked by .alpha. and .beta. have both R or S configuration is described.

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patent: 4973745 (1990-11-01), Blaschke et al.
patent: 4983765 (1991-01-01), Lukas
patent: 5202484 (1993-04-01), Villa et al.
The Merck Index, 11th Edition, Merck & Co., Inc., 1989, p. 657.
"Crystallization-Induced Aymmetric transformations," Enantiomers, Racemates, and Resolutions, Jean Jacques, Andre Collet, Samuel Wilen, 1981, pp. 369-377.
"Enantiomeric separation of chiral carboxylic acids, as their diastereomeric carboxamides, by a thin-layer chromatography," P. Slegel, G. Vereczkey-Donath, L. Ladanyi and M. Toth-Lauritz, Journal of Pharmaceutical & Biomedical Analysis, vol. 5, No. 7, pp. 665-673, 1987.

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