Process for the preparation of the enant iomeric forms of...

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing heterocyclic carbon compound having only o – n – s,...

Reexamination Certificate

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C435S117000, C435S280000

Reexamination Certificate

active

06908752

ABSTRACT:
The present invention relates to a process for the preparation of the enantiomeric forms of 2-substituted 2-(2,5-dioxoimidazolidin-1-yl)acetic acid derivatives of the formula I,wherein R1, R2and R3have the meanings given in the claims, by stereodifferentiating conversion of mixtures of the enantiomers with the aid of enzymes.

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patent: 6331552 (2001-12-01), Wehner et al.
patent: 6399643 (2002-06-01), Wehner et al.
patent: 0 149 674 (1985-07-01), None
patent: WO 99/60015 (1999-11-01), None
Haslam, Edwin, Recent Developments in Methods For The Esterification And Protection Of The Carboxyl Group, Tetrahedron, vol. 36., (1980), pp. 2409-2433.
Mammaghani, M, Enzymatic Kinetic Resolution of Aromatic Substituted Norbomene Mono-Esters Using Pig's Liver Esterase, Tetrahedron, vol. 58, (2002), pp. 147-151.
Roberti, Marinella, et al., Pig Liver Esterase (PLE)-Mediated Resolution of N-Substituted 4-Benzoyloxy-3-Carbomethoxypiperidines: A Convenient Preparation of 4-Hydroxy- And 4-Benzoyloxy-3-Carbomethoxypiperidines in Enantiomerically Pure Form, Tetrahedron, 11(2000), 4397-4405.
Salomon, Claudio, et al., Recent Developments In Chemical Deprotection of Ester Functional Groups, Tetrahedron, vol. 49, (1993), pp. 3691-3734.
Xiao, Xiao-yi, et al., Selective Solid Phase Synthesis of Ureas And Hydantoins From Common Phenyl Carbamate Intermediates, J. Org. Chem., 62, (1997), pp. 6968-6973.

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