Process for the preparation of the anhydride of N-formyl-L-aspar

Details Process for the preparation of the anhydride of N-formyl-L-aspar Process for the preparation of the anhydride of N-formyl-L-aspar

1983-07-18

1985-07-02

Jiles, Henry R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D30766

Patent

active

045269858

ABSTRACT:
A process for the preparation of the anhydride of N-formyl-L-aspartic acid by reacting L-aspartic acid with nearly stoichiometric amounts of formic acid and acetic anhydride, under controlled conditions of temperature, reaction and addition times. The product is a known intermediate in the synthesis of .alpha.-L-aspartyl-L-phenylalanine methyl ester, a known sweetening agent.

REFERENCES:
Stevens et al., Recueil Trax. Chim., 83 (8), pp. 863-872, (1964).
Org. Syntheses, vol. 50, pp. 1-3.
Huffman, J. Org. Chem. 23, pp. 727-729 (1958).
Reese et al., J. C. S. Perkin I, pp. 934-939, (1975).

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