Process for the preparation of tetrahydrothieno[3,2-c]...

Details Process for the preparation of tetrahydrothieno[3,2-c]... Process for the preparation of tetrahydrothieno[3,2-c]...

2006-06-13

2006-06-13

Seaman, D. Margaret (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C546S114000, C556S465000, C556S489000

Reexamination Certificate

active

07060831

ABSTRACT:
A process for the preparation of tetrahydrothieno[3,2-c]pyridine compound of formula 6:or their pharmaceutically acceptable salts, wherein the meaning of X is carboxyl, alkoxycarbonyl, aryloxycarbonyl, or carbamoyl of formulawherein R1and R2can be individually or simultaneously hydrogen, alkyl or part of a heterocyclic structure; Z can be hydrogen, halogen, alkyl, aryl, aryloxy or alkoxy group, the process comprising conducting a dehydroxylation reaction on the compound of formula 5 in order to obtain a compound of formula 6, wherein said dehydroxylation reaction is effected by iodosilane represented by the formula Si(R3)3I, wherein R3selected from an alkyl, alkenyl, alkynyl, aromatic group, or combinations of thereof

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