Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system
Patent
1989-06-29
1991-04-09
Daus, Donald G.
Organic compounds -- part of the class 532-570 series
Organic compounds
Four or more ring nitrogens in the bicyclo ring system
C07D47504
Patent
active
050066552
ABSTRACT:
For the preparation of 5,10-methenyl-(6R)-, 5-formyl-(6S)- or 5-methyl-(6S)-tetrahydrofolic acid or salts thereof, 5,10-methenyl-(6R,S)-tetrahydrofolic acid, the inner salt thereof or one of the salts thereof with strong acids is subjected to diastereomer separation by fractional crystallization and, if desired, the resulting 5,10-methenyl-(6R)-tetrahydrofolic acid is converted by treatment with a hydrolyzing agent into 5-formyl-(6S)-tetrahydrofolic acid or by treatment with a reducing agent into 5-methyl-(6S)-tetrahydrofolic acid, and the resulting free acid may be converted into one of its salts by treatment with a base.
REFERENCES:
patent: 2688018 (1954-08-01), Cosulich
patent: 4959472 (1990-09-01), Wood et al.
Erteilungsbeschluss: German P 38 21 875.5-44 with English translation.
Chem. Abstracts, vol. 107, entry 214060w (1987).
Merck Index, 10th Edition (1983), entry 4111.
Russian article: Kaplan et al., Biologiceskie Nauki, vol. 7, pp. 33-37 (1987).
Fontecilla-Camps et al., Chemistry and Biology of Pteridines, p. 235, Elsevier/North Holland, N.Y.
Cosulich, Journal of the American Chemical Society, vol. 24, Aug. 20, 1952, No. 16, pp. 4125-4216.
Fontecilla-Camps et al., Journal of the American Chemical Society, 101:20/Sep. 26, 1979, pp. 6114-6115.
Feeney, Biochemistry, 1961, 20, 1837-1842.
Tetrahedron, vol. 42, No. 1, pp. 117-136, 1986, Rees et al.
J. Chem. Soc., Chem. Commun., 1987, pp. 470-472, Rees et al.
Kaufman et al, The Journal of Biological Chemistry, vol. 238, No. 4, Apr. 1963, pp. 1498-1500.
The Journal of Biological Chemistry, vol. 253, No. 1, Jan. 10, 1978, pp. 242-245, White et al.
Fachlexikon ABC Chemie, Stereoisomeric, p. 1077, 1987.
Rome, Analytical Biochemistry, 22, 166-177 (1986).
Analytical Biochemistry, 168, 398-404 (1988), Choi et al.
Folates and Pterins, vol. 1, Chemistry and Biochemistry of Folates, 1984, pp. xiii and 99.
Helvetica Chemica Acta-vol. 64, Fasc. 8 (1981)-No. 266, p. 2627, Kalbermatten et al.
Chem. Abstr., vol. 98, entry 215624r (1983).
Conti Josef
Muller Hans R.
Murdel Gunter
Ulmann Martin
Daus Donald G.
Eprova AG
LandOfFree
Process for the preparation of tetrahydrofolates does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Process for the preparation of tetrahydrofolates, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the preparation of tetrahydrofolates will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2036010