Process for the preparation of tetraethyl methylenebisphosphonat

Details Process for the preparation of tetraethyl methylenebisphosphonat Process for the preparation of tetraethyl methylenebisphosphonat

1996-03-12

1997-11-18

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Phosphorus esters

C07F 940

Patent

active

056889836

ABSTRACT:
This invention relates to a process for the preparation of tetraethyl methylenebisphosphonate by the reaction of dichloromethane with diethyl phosphite, wherein the reaction is performed in a polar aprotic solvent or mixtures thereof.

REFERENCES:
G.M. Kosolapoff, "The Chemistry of Aliphatic Phosphonic Acids, I. Alkylation of Methanediphosphonic Acid," Journal of the American Chemical Society, vol. 75, 1500-1501 (1952).
O.E.O. Hormi et al., "A Cheap One-Pot Approach to Tetraethyl Methylenediphosphonate," Synthetic Communications, 20(12), 1865-1867 (1990).
Guozheng Liu, "Improved synthesis of tetraethyl methylenediphosphonate" Yingyong Huaxue Oct. 1995 12(5) 103-104.

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