Process for the preparation of taxol and 10-deacetyltaxol

Details Process for the preparation of taxol and 10-deacetyltaxol Process for the preparation of taxol and 10-deacetyltaxol

1987-07-14

1989-08-15

Hollrah, Glennon H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549510, C07D50514

Patent

active

048576530

ABSTRACT:
Taxol and 10-deacetyltaxol are prepared from a compound of formula: ##STR1## in which R' represents acetyl or 2,2,2-trichloroethoxycarbonyl radical, by removal of the t-butoxycarbonyl radical, benzoylation of the amine product obtained, and removal of the 2,2,2-trichloroethoxycarbonyl group(s).

REFERENCES:
V. Senilh et al., C.R. Acad.Sc. Paris, t. 299, Serie II, No. 15 (1984), pp. 1039-1043.
M. E. Jung et al., Jour.Chem.Soc., Chem.Comm. (1978), pp. 315-316.
R. S. Lott et al., Jour.Chem.Soc., Chem.Comm. (1979), pp. 495-496.
E. Herranz et al., Jour.Am.Chem.Soc., vol. 100:11 (1978), pp. 3596-3598.
Theodora W. Greene, Protective Groups in Organic Synthesis, (1981), pp. 223-225 and 232.

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