Process for the preparation of tablets with retarded liberation

Drug – bio-affecting and body treating compositions – Identification or warning feature – Taste or smell or chemical irritation to the eye – nose – or...

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Details

424 22, A61K 922, A61K 924, A61K 952

Patent

active

043518257

ABSTRACT:
A process for the preparation of matrix-type tablets with retarded liberation of the active agent. The liberation of the active agent from the tablets takes place at a speed that has been adjusted precisely in advance. In the granulation process, polymethacrylate plastics insoluble in neutral or slightly acid water either as dissolved in an organic solvent or as a water dispersion are used as the retarding matrix substance. Before the tablets are compressed, an ester of a large-molecule fatty acid or a product obtained from same by means of hydrogenation is mixed into the grain mix in order to adjust the rate of liberation of the active agent.

REFERENCES:
patent: 2987445 (1961-06-01), Levesque
patent: 3062720 (1962-11-01), Costello
patent: 3148124 (1964-09-01), Gaunt
patent: 3577512 (1968-10-01), Shepherd et al.

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