Process for the preparation of substituted tetrahydrofolico deri

Details Process for the preparation of substituted tetrahydrofolico deri Process for the preparation of substituted tetrahydrofolico deri

1992-10-07

1994-09-27

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

544259, 544260, C07D47504

Patent

active

053508505

ABSTRACT:
Process for the preparation of the optically active [6(S)(-)]N.sup.5 alkaline earth metal salts of methyltetrahydrofolic acid and formyltetrahydrofolic acid wherein an aqueous solution of folic acid is hydrogenated with a high stoichiometric excess of sodium borohydride followed by treating the reaction product with formic aldehyde and optionally further with sodium borohydride when the methyl derivative is desired. Reaction with a salt of the alkaline earth metal precipitates the desired optically active alkaline earth metal salt.

REFERENCES:
patent: 5124452 (1992-06-01), Gennari
patent: 5194611 (1993-03-01), Marazza et al.

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