Process for the preparation of substituted quinazoline-2,4,-dion

Details Process for the preparation of substituted quinazoline-2,4,-dion Process for the preparation of substituted quinazoline-2,4,-dion

1994-11-15

1996-07-23

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C07D23996

Patent

active

055391141

ABSTRACT:
A process for the preparation of quinazoline-2,4-diones of the formula (I) ##STR1## in which R.sup.1 is aryl and R.sub.2, R.sup.3, R.sup.4, and R.sup.5 independently of one another are halogen, alkyl, alkoxy or hydrogen, by reacting anthranilic acid esters of the formula (II) ##STR2## in an aprotic reaction medium with aryl isocyanates R.sup.1 --N.dbd.C.dbd.O to give N-arylcarbamoyl-anthranilic acid esters of the formula (III) ##STR3## and cyclizing these in the presence of a base selected from the group of alkali metal or alkaline earth metal alkoxides, amides, hydrides or tetraalkylammonium hydroxides.

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