Process for the preparation of substituted pentaalkylchromenes

Details Process for the preparation of substituted pentaalkylchromenes Process for the preparation of substituted pentaalkylchromenes

1993-09-15

1994-04-19

Chan, Nicky

Organic compounds -- part of the class 532-570 series

Organic compounds

Cyclohexadiene having atoms double bonded directly at the 1-...

C07C 5006

Patent

active

053046633

ABSTRACT:
A novel process for the preparation of pentaalkylchromenes of the general formula: ##STR1## wherein R denotes a lower alkyl group having 1 to 4 C atoms and R.sub.1 denotes a phenyl group which is unsubstituted or substituted by a lower alkyl group having 1 to 4 C atoms, by halogen or by a nitro group, or an alkanoyl group having 1 to 4 C atoms. In the process, a trialkylhydroquinone is reacted with a halogenated butenol to give a substituted tetraalkyhydroquinone, which is oxidized. Then the halogen atom is substituted with a suitable nucleophile and the compound is finally cyclized to give the final product. The pentaalkylchromenes are suitable intermediates for the preparation of hypolipidaemic pharmaceuticals.

REFERENCES:
J. Med. Chem., 32, (1989), pp. 421 to 428.

Affiliated with

Also associated with

Rating

Process for the preparation of substituted pentaalkylchromenes does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the preparation of substituted pentaalkylchromenes, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the preparation of substituted pentaalkylchromenes will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-20703