Process for the preparation of substituted isoxazolo[4,5-c]pyrid

Details Process for the preparation of substituted isoxazolo[4,5-c]pyrid Process for the preparation of substituted isoxazolo[4,5-c]pyrid

1977-04-26

1978-09-12

Randolph, John D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

42424854, 424250, 424263, 26029359, 260296H, 544127, 544367, C07D49104

Patent

active

041137272

ABSTRACT:
An improved process for the preparation of substituted isoxazolo[4,5-c]pyridin-4(5H)-ones which are either useful as intermediates in the preparation of compounds having pharmaceutical activity or as hypolipidemic agents which comprises cyclizing a corresponding 5-(2-amino-2-phenyl- or substituted phenyl-ethenyl)-3-substituted-N-alkyl isoxazole-4-carboxamide under acidic conditions.

REFERENCES:
patent: 4049813 (1977-09-01), Nadelson
Anker et al, J. Chem. Soc. 1941, pp. 323 to 331.

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