Process for the preparation of substituted cyclopropanecarbaldeh

Details Process for the preparation of substituted cyclopropanecarbaldeh Process for the preparation of substituted cyclopropanecarbaldeh

1990-01-30

1990-11-06

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Sulfonic acids or salts thereof

549475, 568 41, 568583, 568588, 568649, 568655, 568662, 568663, 568669, 568681, 568683, 568684, C07C30302, C07C32322

Patent

active

049688367

ABSTRACT:
The invention relates to a process for the preparation of cyclopropanecarbaldehydes of formula ##STR1## in which R.sub.1 is C.sub.1 -C.sub.4 alkyl or benzyl, which comprises (a) reacting a tetrahydrofuran of formula ##STR2## in which X is halogen and R.sub.2 is unsubstituted or halo-substituted C.sub.1 -C.sub.10 alkyl, C.sub.3 -C.sub.6 -cycloalkyl that is unsubstituted or substituted by halogen, C.sub.1 -C.sub.4 alkyl or by C.sub.1 -C.sub.4 alkoxy, or phenyl or benzyl each of which is unsubstituted or substituted by halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, nitro or cyano, with a halogenating agent to form a 1,2,4-trihalobutyl ether of formula ##STR3## in which X is halogen and R.sub.2 is unsubstituted or halo-substituted C.sub.1 -C.sub.10 alkyl, C.sub.3 -C.sub.6 cycloalkyl that is unsubstituted or substituted by halogen C.sub.1 -C.sub.4 alkyl or by C.sub.1 -C.sub.4 alkoxy, or phenyl or benzyl each of which is unsubstituted or substituted by halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, nitro or cyano, and

REFERENCES:
patent: 3239560 (1966-03-01), Cambre et al.
patent: 3721711 (1973-03-01), Maravetz
Chem. Zvesti 1971, 25, 9, M. Holik et al..
Collect Czech. Chem. Comm. 1970, 35, 1745; V. Zezula et al.
Khim. Geterotsicl. goedin 1968, 4, 200, L. M. Bolotina et al.
Coll. Czech. Chem. Comm. 25, 1351-8 (1960), M. Kratochvil.
Chemical Abstract vol. 54--24624 (1960).

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