Process for the preparation of stroma-free hemoglobin solutions

Details Process for the preparation of stroma-free hemoglobin solutions Process for the preparation of stroma-free hemoglobin solutions

1981-08-05

1983-08-30

Rosen, Sam

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Having a known elemental analysis

260112B, 424177, A61K 3514

Patent

active

044016522

ABSTRACT:
A process for preparing a stroma-free hemoglobin solution is provided. The process includes washing blood cells to remove noncellular components to obtain a mixture of erythrocytes and leukocytes. The leukocytes are removed from the mixture and the erythrocytes are lysed to form a mixture of stroma and hemoglobin. The stroma is precipitated from the hemoglobin by treating the stroma-hemoglobin mixture with a polyvalent cation; a polysulfate, and a polyvalent anion. The supernatant hemoglobin solution is separated and dialyzed to obtain a substantially pure hemoglobin solution.

REFERENCES:
patent: 3864478 (1975-02-01), Bonhard
patent: 3903254 (1975-09-01), Dahlgren et al.
patent: 3991181 (1976-11-01), Doczi
patent: 4061736 (1977-12-01), Morris et al.
patent: 4064118 (1977-12-01), Wong
patent: 4136093 (1979-01-01), Bonhard et al.

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