Process for the preparation of stereoisomers of 1-aminoalkylphos

Details Process for the preparation of stereoisomers of 1-aminoalkylphos Process for the preparation of stereoisomers of 1-aminoalkylphos

1985-09-09

1989-08-22

Warren, Charles F.

Chemistry: molecular biology and microbiology

Process of utilizing an enzyme or micro-organism to destroy...

Resolution of optical isomers or purification of organic...

435128, 435129, 2605024R, 562 15, C12P 4100

Patent

active

048596027

ABSTRACT:
The present invention provides a process for the preparation of the stereoisomers of 1-aminoalkylphosphonic acids and of 1-aminoalkylphosphinic acids by enzymatic resolution of their racemic N-acyl derivatives and subsequent deacylation, wherein the enzymatic resolution is carried out with penicillin G amidase.

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patent: 4235973 (1980-11-01), Tschang et al.
patent: 4247643 (1981-01-01), Kramer et al.
patent: 4389488 (1983-06-01), Grabley et al.
Otvos et al, Biochem. and Biophys. Res. Comm., vol. 44, No. 5, pp. 1056-1064 (1971).
Rossi et al, J. Org. Chem., vol. 43, No. 13 (1978), pp. 2576-2581, 2222-2225.
Romeo et al, Tetrahedron Ltrs., No. 21, pp. 1799-1802 (1971).
J. Telegdi, et al.: "Enzymatic Resoluton of Alpha-Aminophosphonic Acids", pp. 221-225, Hungarian Acad. of Sciences.
Chemical Abstracts, vol. 101, (1984), 53353c.

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