Process for the preparation of stable dispersions of at least on

Details Process for the preparation of stable dispersions of at least on Process for the preparation of stable dispersions of at least on

1988-03-14

1991-10-08

Scalzo, Catherine S. Kilby

Compositions

Preservative agents

Anti-corrosion

2523152, 2523156, 264 41, B01J 1300

Patent

active

050552287

ABSTRACT:
A process for the preparation of a stable emulsion of at least one water-immiscible liquid phase L in an aqueous phase D is described which comprises mixing the liquid phase or phases L with a dispersion of spheres in an aqueous phase D, the spheres having an average diameter of 0.025 to 5 microns and consisting of substantially concentric lipid laminae encapsulating an aqueous phase E between them, the lipid or lipids constituting the laminae being ionic or nonionic amphiphilic substances capable of forming a lamellar phase in water, and subjecting the whole to mechanical agitation so as to disperse the phase (or phases) L in the phase D in the form of droplets having an average diameter of 0.1 micron to a few microns.

REFERENCES:
patent: 3957971 (1976-05-01), Oleniacz
patent: 4217344 (1980-08-01), Vanlerberghe et al.
patent: 4224179 (1980-09-01), Schneider
patent: 4776976 (1988-10-01), Nakamura et al.
patent: 4776991 (1988-10-01), Farmer et al.
patent: 4789633 (1988-12-01), Huang et al.
Duzgunes and Ohki, "Fusion of Small Liposomes", 6/27/80, Biochimica et Biophisica Acta, 640 (1981) 734-747.
Chemical Abstracts, vol. 85, No. 4, Jul. 26, 1976, Ref. 25402a, p. 258.

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