Process for the preparation of stable complex multiple emulsions

Details Process for the preparation of stable complex multiple emulsions Process for the preparation of stable complex multiple emulsions

1994-01-10

1995-12-26

Venkat, Jyothsna

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Cosmetic, antiperspirant, dentifrice

514938, 514939, 514940, 514941, 514943, A61K 700

Patent

active

054785618

ABSTRACT:
The invention relates to a novel process for the preparation of stable complex multiple emulsions of the water-oil-water type which are well suited for use in cosmetic preparations. The primary emulsions of the W/O type are prepared in the presence of both a non-ionic polymeric lipophilic emulsifier and a non-ionic polymeric stabiliser each preferably having an HLB value in the range from 6 to 10. In a second process step more water containing a hydrophilic emulsifier having a higher HLB value, preferably in the range from 12 to 25, is added to the primary emulsion until phase inversion occurs. It is important that the procedure in this second process step is not reversed, i.e. that the primary emulsion is not added to the aqueous phase. Further active substances, such as UV filters and vitamins, may be added to the aqueous or oil phase respectively. In a third process step hydrating agents and/or gelling agents may be added, thus increasing the viscosity without impairing the stability of the multiple emulsion.

REFERENCES:
patent: 4714566 (1987-12-01), Takahashi et al.
patent: 4985250 (1991-01-01), Bee et al.
Stabilization . . . Release, T. K. Law, Journal of Controlled Release, 3: 279-290 (1986), Elsevier Science Publishers B.V. Amsterdam.
Grant and Hack's Chemical dictionary p. 578, 1987.

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