Process for the preparation of stabilized isosorbide-5-mononitra

Details Process for the preparation of stabilized isosorbide-5-mononitra Process for the preparation of stabilized isosorbide-5-mononitra

1986-10-14

1989-03-14

Schofer, Joseph L.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

514464, A61L 1503

Patent

active

048123161

ABSTRACT:
The present invention relates to obtaining isosorbide-5-mononitrate tablets, being also of retard form, which are stable in time. Such embodiment is now possible after the discovery of the stabilizing activity of the with respect to the isosorbide-5-mononitrate with which it forms a solid solution. The use of PVP is essential so that the tablets can remain stable in time: the retard effect in turn can be obtained with the use of hydroxyalkylcelluloses.

REFERENCES:
patent: 3972995 (1976-08-01), Tsuk et al.
patent: 4291015 (1981-09-01), Keith et al.
patent: 4482534 (1984-11-01), Blank

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