Process for the preparation of spherules of active principles an

Details Process for the preparation of spherules of active principles an Process for the preparation of spherules of active principles an

1994-03-31

1996-03-19

Wityshyn, Michael G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530354, 530410, 530419, 530427, 424456, 424492, 5483037, 544327, 552653, 562569, 568824, A61K 916, A61K 964, C07K 132, C07K 14435

Patent

active

055004156

ABSTRACT:
A process for the preparation of spherules and emulsions containing such spherules. A primary oil-in-water emulsion is formed containing particles comprising one or more active principles in oily form suspended in water, the water optionally containing at least one protein. Controlled division of the primary emulsion is achieved by combining the primary emulsion with a water-immiscible solvent to create a second emulsion containing spherules of the primary emulsion. Preferably, the particles of the primary emulsion have mean diameters of about 1 .mu.m, and preferably, the spherules contained in the second emulsion have a diameter ranging from 100 .mu.m to 500 .mu.m. If protein is contained in the primary emulsion, the protein can be cross-linked. Further, the spherules can be separated from the water-immiscible solvent.

REFERENCES:
patent: 2828202 (1958-03-01), Rosenberg
patent: 3202731 (1965-08-01), Grevenstulr et al.
patent: 3956172 (1976-05-01), Saeki et al.
patent: 4929774 (1990-05-01), Fukamachi et al.
patent: 5035896 (1991-07-01), Apfel et al.

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