Process for the preparation of somatostatin

Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal

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2601125R, C07C10352

Patent

active

043371949

ABSTRACT:
The present invention relates to a new process for the stepwise preparation of somatostatin enabling a product of high purity to be obtained, with high yields, from cysteine in 14 position whose acid function is protected by the phenylazobenzylsulfonylethyloxy group and thiol function is protected by the acetamidomethyl group, all the peptide coupling reactions being effected in liquid phase in the dimethylformamide, the intermediate peptides being precipitated by addition of a second solvent and purified in solid phase by washing with the aid of suitable solvents dissolving the impurities.

REFERENCES:
patent: 3917578 (1975-11-01), Immer et al.
patent: 3917581 (1975-11-01), Immer et al.
patent: 4216141 (1980-08-01), Rivier et al.

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