Process for the preparation of solifenacin

Details Process for the preparation of solifenacin Process for the preparation of solifenacin

2007-06-21

2011-10-11

Seaman, D M (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

08034942

ABSTRACT:
A process for the preparation of (1S)-QR)-I-azabicyclo[2.2.2.]oct-3-yl 3,4-dihydro-1-phenyl-2(1H)-isoquinoline carboxylate by reacting (1S)-alkyl 1-phenyl-1,2,3,4-tetrahydro-2-isoquinoline carboxylate with 3-(R)-quinuclidol in an inert solvent, where a primary alkyl ester of the carboxylate whose alkyl length is C1-C4is used and the reaction is catalyzed by a non-nucleophilic base.

REFERENCES:
patent: 2009/0326230 (2009-12-01), Mathad et al.
patent: 0 801 067 (1997-10-01), None
patent: 1 726 304 (2006-11-01), None
patent: WO 96/20194 (1996-07-01), None
patent: WO 2005/087231 (2005-09-01), None
Naito et al., Journal of Medicinal Chemistry (2005), 48(21), 6597-6606.
International Search Report for International Application No. PCT/CZ2007/000061 mailed Feb. 25, 2008.

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