Process for the preparation of rifampicin

Details Process for the preparation of rifampicin Process for the preparation of rifampicin

1978-09-27

1979-11-13

Ford, John M.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424244, 42424854, 424267, C07D49818

Patent

active

041743202

ABSTRACT:
The present invention provides a process for the preparation of rifampicin, wherein rifamycin S is reacted in an aprotic dipolar solvent with a 1,3,5-trisubstituted hexahydro-1,3,5-triazine at a temperature from 20.degree. to 100.degree. C. followed by reaction with 1-amino-4-methylpiperazine, while keeping the pH in the range of from 5 to 7, whereafter the rifampicin formed is isolated.

REFERENCES:
patent: 3342810 (1967-09-01), Maggi et al.
patent: 3925366 (1975-12-01), Marsili et al.
patent: 3963705 (1976-06-01), Marsili et al.

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