Process for the preparation of radiolabeled meta-halobenzylguani

Details Process for the preparation of radiolabeled meta-halobenzylguani Process for the preparation of radiolabeled meta-halobenzylguani

1994-07-20

1996-10-15

Hollinden, Gary E.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

In an organic compound

564237, 564238, A61K 5104, C07C27700

Patent

active

055651852

ABSTRACT:
The present invention provides a no-carrier-added synthesis of radiolabeled meta-halobenzylguanidine by halodestannylation which comprises reacting a meta-trialkylstannylbenzylguanidine with a source of radionuclide of a halogen. The present invention also provides meta-trialkylstannylbenzylguanidine as intermediates in the afore-mentioned process.

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Sexton et al., Soc. Neurosci. Abstr. 17(1-2) (1991).
Wafelman et al., "Synthesis, Radiolabeling and Stability of Radioiodirated m-Iodobenzylguanidine, a Review", Appl. Radiat. Isot., vol. 45, No. 10 pp. 997-1007, (1994).
Vaidyanathan et al., Appl. Radiat. Isot., vol. 44, No. 3, pp. 621-628 (1993).
Weiland et al., J. Nucl. Med., vol. 21, No. 4, pp. 349-353 (1980).
Mangner et al., J. Org. Chem., vol. 47, pp. 1484-1488 (1982).
The Lancet, pp. 905-907 (1984).

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