Process for the preparation of (r)- or (s)-aminocarnitine...

Details Process for the preparation of (r)- or (s)-aminocarnitine... Process for the preparation of (r)- or (s)-aminocarnitine...

2005-10-11

2005-10-11

Zucker, Paul A. (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

Reexamination Certificate

active

06953865

ABSTRACT:
A process for the production of (R)- or (S)-aminocarnitine starting respectively from (R)- or (S)-nitryloxycarnitine, through the formation and hydrogenation of the azidocarnitine intermediate with the same absolute configuration is described. (R)-aminocarnitine inner salt is obtained after purification, which is then converted into non-deliquescent salts. Also a process for the preparation of derivatives of (R)- and (S)-aminocarnitine, in particular acylayed or ureic derivatives, having known pharmacological properties, starting from (R)- and (S)-aminocarnitine salts, releasing the aminic function in situ.

REFERENCES:
patent: 4767781 (1988-08-01), Shinagawa et al.
patent: 0 636 603 (1995-02-01), None
patent: WO 99/59957 (1999-11-01), None
patent: 01 10819 (2001-02-01), None
Deborah L. Jenkins et al.: “DL-Aminocarnitine and Acetyl-DL-aminocarnitine” The Journal of Biomedical Chemistry; vol. 260, No. 27, 1985, pp. 14748-14755 XP002221696 figure 1.
Roberto Castagnani et al.:“Stereospecific Synthesis of (R)-Aminocarnitine (Emeriamine) Starting form (R)-Carnitine Via Double Inversion of Configuration” Journal of Organic Chemistry, vol. 60, No. 25, 1995, pp. 8318-8319, XP002221697 p. 8319, Scheme 1, Experimental Section.

Affiliated with

Also associated with

Rating

Process for the preparation of (r)- or (s)-aminocarnitine... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the preparation of (r)- or (s)-aminocarnitine..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the preparation of (r)- or (s)-aminocarnitine... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3457068