Organic compounds -- part of the class 532-570 series – Organic compounds – Oxygen containing
Reexamination Certificate
2005-04-19
2005-04-19
Keys, Rosalynd (Department: 1621)
Organic compounds -- part of the class 532-570 series
Organic compounds
Oxygen containing
C568S610000, C568S630000, C568S648000, C568S649000, C568S651000, C568S656000, C568S658000, C568S715000, C568S812000, C560S055000, C560S060000, C560S064000
Reexamination Certificate
active
06881868
ABSTRACT:
Compounds of formula (I), wherein R1and R2are, independently of one another, H,C1-C6alkyl, C1-C6halogenalkyl, C1-C6alkoxyl, C1-C6alkoxy-C1-C6alkyl, or C1-C6alkoxy-C1-C6alkyloxy, and R3is C1-C6alkyl, are obtainable in high yiedls by stereoselective addition of R3-substituted propionic acid esters to R1- and R2-substituted benzaldehydes of formula R—CHO to form corresponding 3-R-3-hydroxy-2-R3-propionic acid esters, conversion of the OH group to a leaving group, subsequent regioselective elimination to form 3-R-2-R3-propenic acid esters, and reduction to corresponding 3-R-2-R3-allyl alcohols and their enantioselective hydrogenation, wherein R is (a).
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Herold Peter
Spindler Felix
Sturm Thomas
Stutz Stefan
Weissensteiner Walter
Keys Rosalynd
Speedel Pharma AG
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