Process for the preparation of quinolonecarboxylic acids which c

Details Process for the preparation of quinolonecarboxylic acids which c Process for the preparation of quinolonecarboxylic acids which c

1988-04-15

1990-11-27

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5142245, 5142282, 5142285, 5142302, 5142332, 5142335, 5142345, 514294, 514300, 514312, 544 60, 544 61, 544 62, 544126, 544127, 544128, 544349, 544363, 546122, 546123, 546156, C07D40104, A61K 31495

Patent

active

049735900

ABSTRACT:
Known quinolone carboxylic acid derivatives of the formula ##STR1## are treated so as to become readily administrable parenterally, the treatment comprising dissolving the active compound using an acid, allowing the solution to stand for about 0.15 to 150 hours at a temperature from room temperature to the boiling point of the solution, filtering the solution, precipitating the active compound from the solution using a basic reagent, and converting the precipitated active compound into a form which can be administered parenterally.

REFERENCES:
patent: 4292317 (1981-09-01), Pesson
patent: 4616019 (1986-10-01), Chu
patent: 4638067 (1987-01-01), Culbertson et al.
patent: 4705789 (1987-11-01), Grohe et al.
Fundamentals of Analytical Chemistry, (3rd. Ed.), by Skoog and West, pp. 7, 127-130 (1976).

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