Process for the preparation of quinoline carboxylic acids

Details Process for the preparation of quinoline carboxylic acids Process for the preparation of quinoline carboxylic acids

1991-09-06

1994-04-05

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544229, 546110, C07D40104

Patent

active

053006445

ABSTRACT:
The invention relates to a new process for the preparation of compounds of the general Formula I ##STR1## wherein R stands for piperazinyl, 4-methyl-piperazinyl or 4-ethyl-piperazinyl group and pharmaceutically acceptable salts thereof which comprises reacting a compound of the general Formula II ##STR2## wherein R.sup.1 and R.sup.2 stand for halogen, for an aliphatic acyloxy group containing 2 to 6 carbon atoms and optionally substituted by halogen, or for an aromatic acyloxy group containing 7 to 11 carbon atoms with a piperazine derivative of the general Formula III ##STR3## wherein R.sup.3 stands for hydrogen, methyl or ethyl or a salt thereof and subjecting the compound of the general Formula IV ##STR4## thus obtained wherein R, R.sup.1 and R.sup.2 are as stated above to hydrolysis after or without isolation and if desired converting the compound of the general Formula I thus obtained into a salt thereof or setting free the same from its salt.
The compounds of the general Formula I are known antibacterial agents.

REFERENCES:
patent: 4806645 (1989-02-01), Hermecz et al.
patent: 4940710 (1990-07-01), Sum et al.
Derwent Abstracts, vol. 8, No. 241, 1984.(Abstract of Japanese Patent 59-122470(A), Jul. 14, 1984.

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