Process for the preparation of pyrrolo[2,3-d]pyrimidines

Details Process for the preparation of pyrrolo[2,3-d]pyrimidines Process for the preparation of pyrrolo[2,3-d]pyrimidines

1991-12-04

1993-10-19

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C07D48704

Patent

active

052546870

ABSTRACT:
5-Substituted pyrrolo[2,3-d]pyrimidines are prepared from a nucleophile of the formula R.sup.2 -C(.dbd.NH)NH.sub.2 and a 2-amino-5-substituted-furan carrying a cyano or carboxy group in the 4-position. A typical example is the preparation of ethyl 4-(2-(2,4-diaminopyrrolo[2,3-d]pyrimidin-5-yl)ethyl}benzoate, an intermediate for the preparation of the known N-[4-{2-(2,4-diaminopyrrolo[2,3-d]pyrimidin-5-yl)ethyl}benzoyl]-L-glutamic acid, by allowing guanidine and ethyl 4-[2-(2-amino-3-cyanofur-4-yl)ethyl]benzoate to react under mild conditions.

REFERENCES:
patent: 3706770 (1972-12-01), Graf et al.
patent: 4439225 (1984-03-01), Kollmeyer

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