Process for the preparation of pyroglutamyl-Ala-Lys-Ser-Gln-Gly-

Details Process for the preparation of pyroglutamyl-Ala-Lys-Ser-Gln-Gly- Process for the preparation of pyroglutamyl-Ala-Lys-Ser-Gln-Gly-

1977-03-14

1978-07-04

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07C10352

Patent

active

040987779

ABSTRACT:
This invention is directed to the chemical process for the preparation of the polypeptide, pyroglutamyl-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn and to intermediates in said process. The polypeptide prepared by the present process is useful in the treatment of autoimmune diseases such as Lupus like pathology and specifically for the treatment of Lupus Erythematosus in man. This polypeptide is also useful for selectively stimulating T-cell activity in aging subjects.

REFERENCES:
J. Bach, et al., Nature 266, 55 1977.
Wolters, et al., J. Org. Chem. 39, 1974 pp. 3388-3392.

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