Process for the preparation of pyrimidine derivatives

Details Process for the preparation of pyrimidine derivatives Process for the preparation of pyrimidine derivatives

1988-12-22

1990-02-13

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C07D23952

Patent

active

049008277

ABSTRACT:
4,6-Bis(difluoromethoxy)pyrimidines of formula I ##STR1## wherein R is C.sub.1 -C.sub.4 alkyl or unsubstituted or substituted phenyl or benzyl, are prepared by reacting a 4,6-dihydroxypyrimidine dialkali metal salt of formula II ##STR2## wherein R is as defined for formula I and Me is an alkali metal, with chlorodifluoromethane in a solvent selected from the group consisting of ketones and alkyl cyanides, in the presence of 0.05 to 1.1 mol of water per mol of dialkali metal salt of formula II.

REFERENCES:
patent: 4500344 (1985-02-01), Freerksen
patent: 4542216 (1985-09-01), Pfluger
patent: 4545811 (1985-10-01), Meyer et al.
patent: 4692524 (1987-09-01), Hassig
Meyer et al., CA 98-215616q (1983).
Freerksen et al., CA 101-7181x (1984).

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