Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system
Patent
1986-02-14
1988-10-04
Daus, Donald G.
Organic compounds -- part of the class 532-570 series
Organic compounds
Four or more ring nitrogens in the bicyclo ring system
C07D23926
Patent
active
047757558
ABSTRACT:
The invention provides a process for the preparation of pyrimidine, 2-methyl- and/or 2-ethylpyrimidine, characterized in that for pyrimidine a nitrogen reactant, chosen from the reaction product of formamide with 1,3-diaminopropane in the liquid phase, 1-amino-3-formamidopropane, 1,4,5,6-tetrahydropyrimidine and/or 1,3-diformamidopropane, that for 2-methylpyrimidine 1-amino-3-acetamidopropane, 2-methyl-1,4,5,6-tetrahydropyrimidine and/or 1,3-diacetamidopropane, and that for 2-ethylpyrimidine 1-amino-3-propionamidopropane, 2-ethyl-1,4,5,6-tetrahydropyrimidine and/or 1,3-dipropionamidopropane is/are contacted with a palladium-containing catalyst, this being effected in the gas phase at a temperature between 200.degree. and 550.degree. C. and in the presence of a carbon monoxide-hydrogen reactant, and that pyrimidine, 2-methyl-and/or 2-ethyl-pyrimidine is recovered from the reaction mixture obtained.
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Delahaye Hubertus J. A. V.
Teunissen Antonius J. J. M.
van de Moesdijk Cornelis G. M.
Daus Donald G.
Rivers Diana G.
Stamicarbon B. V.
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