Process for the preparation of pyridopyrimidones

Details Process for the preparation of pyridopyrimidones Process for the preparation of pyridopyrimidones

2006-10-10

2006-10-10

McKenzie, Thomas C. (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C544S287000, C544S289000

Reexamination Certificate

active

07119199

ABSTRACT:
The present invention is directed to a method for producing a pyridopyrimidone of the formulawherein X is N or CH and R is an aryl, heteroaryl or alkyl group, said method comprising the step of reacting an acid derivative of the formula:wherein X is N or CH; Y is an appropriate leaving group; Z is a halogen, OR1, NHR1, or SR1; and R1is a lower alkyl; and the amidine derivative iswherein R is an aryl, heteroaryl or alkyl group.

REFERENCES:
Brown, D. J. et a, Australian Journal of Chemistry, 1985 vol. 38, No. 3, pp. 467-474.
Bennett, et al., J. Med. Chem, 1981, 24:382-389.
Ellingboe, et al., J. Med. Chem, 1994, 37:542-550.
Gonzalgo, et al., The Journal of Urology, Aug. 2003, 170:503-506.
LoRusso, et al., Clinical Cancer Research, Jun. 2003, 9:2040-2048.
Tomita et al., J. Med. Chem., 2002, 45:5564-5575.
International Search Report for PCT/US04/44064, mailed Jul. 14, 2005, 2 pgs.
Brown, et al., Australian Journal of Chemistry, 1985, pp. 467-474, vol. 38:3.

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