Process for the preparation of pyridinyl and pyrimidinyl...

Details Process for the preparation of pyridinyl and pyrimidinyl... Process for the preparation of pyridinyl and pyrimidinyl...

2006-11-14

2006-11-14

Balasubramanian, Venkataraman (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C546S302000

Reexamination Certificate

active

07135569

ABSTRACT:
The present invention relates to a process for preparing pyridinyl and pyrimidinyl mono-fluorinated beta keto esters of formula (I):wherein:R1 represents a pyridine ring or a pyrimidine ring, the rings being optionally substituted by a C3-6cycloalkyl group, a C1-4alkyl group, a C1-4alkoxy group, a benzyl group or a halogen atom;R2 represents a hydrogen atom, a C1-6alkyl group or ahalogenatom; andR3 represents a C1-6alkyl group; by reacting with fluorine a compound of formula (II)wherein R1, R2 and R3 have the same meaning as defined above.

REFERENCES:
patent: 1295885 (2003-03-01), None
patent: WO 03/027116 (2003-04-01), None
Linderman, R.J., et. al., Oxidation of Fluoroalkyl-Substituted Carbinols by the Dess-Martin Reagent, Journal of Organic Chemistry, vol. 54, No. 3, pp. 661-668 (1989).
Thenappan, A., et. al., An Expedient Synthesis of A-Fluoro-B-Ketoesters1, Tetrahedron Letters, vol. 30, No. 45 (1989) pp. 6113-6116.

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