Process for the preparation of pyridine-2,3-dicarboxylic acids

Details Process for the preparation of pyridine-2,3-dicarboxylic acids Process for the preparation of pyridine-2,3-dicarboxylic acids

1989-03-31

1992-11-24

Marx, Irene

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing heterocyclic carbon compound having only o, n, s,...

435121, 435877, 435189, C12P 710, C12P 1712, C12N 120, C12N 902

Patent

active

051660601

ABSTRACT:
Pyridine-2,3-dicarboxylic acids are prepared by the action of 2,3-dihydroxybenzoate-3,4-dioxygenase on 2,3-dihydroxybenzoic acids in a liquid medium which lacks active decarboxylase and which has a pH from 4 to 9, an ionic strength below about 1 molar, and a low concentration of metal cations and complex anions. In close temporal proximity, the 2-hydroxy-3-carboxymuconic acid semialdehyde which forms is allowed to react with a source of ammonia or a primary amine, avoiding substantial decarboxylation.

REFERENCES:
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patent: 4654303 (1987-03-01), Hagedorn
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Andreoni et al., Biochem 5, 1981, vol. 194, pp. 607-610.
Fersht, A., "Enzyme Structure and Mechanism", 1984, pp. 311-354, Freeman.

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