Process for the preparation of purine derivatives

Details Process for the preparation of purine derivatives Process for the preparation of purine derivatives

1994-06-10

1997-11-04

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen bonded directly to ring carbon of the purine ring...

544277, C07D47318, C07D47332

Patent

active

056841531

ABSTRACT:
The present invention provides a process for the synthesis of penciclovir and famciclovir by 9-substituting the compound 2-amino-6-chloropurine (ACP) with 2-acetoxymethyl-4-(leaving group)-but-1-yl acetate, followed by displacement of the 6-chloro moiety with a hydroxy moiety (i.e. to form a guanine derivative) or with hydrogen (to form the 2-aminopurine derivative), respectively.

REFERENCES:
patent: 5075445 (1991-12-01), Jarvest et al.
patent: 5246937 (1993-09-01), Harnden et al.
Geen et al., Tetrahedron, 46:19, 6903-6914, (1990).
Chu et al., J. Heterocyclic Chem., 23, 289 (1986).
Robins et al., Can. J. Chem., 60 (1982).
Kjellberg et al., Nucleosides & Nucleotides, 8:2, 225-256 (1989).

Affiliated with

Also associated with

Rating

Process for the preparation of purine derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the preparation of purine derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the preparation of purine derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1834181