Process for the preparation of purine derivatives

Details Process for the preparation of purine derivatives Process for the preparation of purine derivatives

1989-07-21

1991-05-21

Rivers, Diana

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen bonded directly to ring carbon of the purine ring...

544277, C07D47338, C07D47340

Patent

active

050177010

ABSTRACT:
A process for the preparation of a compound of formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## which process comprises reacting a compound of formula (II): ##STR2## wherein the amino group is optionally protected, Y is iodo, optionally substituted benzylthio or (phenacylmethyl)thio, with a compound of formula (III): ##STR3## wherein Q is a leaving group, R.sub.x and R.sub.y are protected hydroxymethyl or acyloxymethyl, or group(s) convertible to hydroxymethyl or acyloxymethyl; and R.sub.z is hydrogen or a group convertible thereto; and thereafter converting Y to X is hydroxy by means of hydrolysis, or to X is hydrogen by means of reduction; converting R.sub.x and R.sub.y when other than hydroxymethyl or acyloxymethyl, to hydroxymethyl or acyloxymethyl, optionally converting R.sub.x /R.sub.y hydroxymethyl to acyloxymethyl or vice versa, deprotecting the 2-amino group where necessary and converting R.sub.z, (when other than hydrogen) to hydrogen; and optionally forming a pharmaceutically acceptable salt thereof.

REFERENCES:
patent: 4347185 (1982-08-01), Muchowski et al.
patent: 4347187 (1982-08-01), Muchowski et al.
patent: 4798833 (1989-01-01), Johansson et al.
patent: 4845084 (1989-07-01), Hannah et al.
Padgett et al., J. Org. Chem., vol. 44, No. 20, pp. 3492-3496 (1979).
Csendes et al., J. Org. Chem., vol. 44, No. 23, pp. 4173-4178 (1979).

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